Here’s an example of pen & ink, with the acrostic embellished with color permanent-ink Faber-Castell pens. Done back in Aught-Eight, when I was writing single-acrostic sonnets like crazy. The umbilicus, nasturtium, opossum and encyclical illustrate the first four lines.

Understandable

Umbilicuses pave the stem cell highway
Nasturtiums have ornamental blossums
Deliciousness sometimes requires opossums
Encyclicals so seldom see things my way.
Rich as a soil may be, if dry, it’s barren.
Soft kisses thrill–OR make the Ticklish jump.
The misbehaving hair may snarl & clump
Albeit seeming fair as Rose of Sharon.
Near Death, Experience is tartly flavored
Deliverance to Death’s Door bad-outrageous
Afflicted oldsters call for Priest or Magus:
Beneficence to help a soul be Favored–
Lo and Be Told: I’ll be a deathbed Coward–
Expect some yelping with this–UNempowered.